Bypassing Agents are a Factor option with a long history of use in treating hemophilia patients with inhibitors
By: Mike Denne
Published: Lifelines for Health, Winter 2017
Treatment of inhibitors is one of the greatest challenges in hemophilia today
Up to 33% of people with severe hemophilia A develop an inhibitor, or antibody, to treatment, while 3% to 13% of patients with moderate to mild hemophilia develop an inhibitor.1,2 (Inhibitors are less common among people with hemophilia B, affecting only 1% to 6% of individuals.1) These inhibitors stop, or block, Factor VIII (FVIII) or Factor IX (FIX) function in your blood-clotting process. Bypassing Agents offer an alternative treatment approach because they go around, or bypass, the need for FVIII or FIX.3
Bypassing Agents supplement other Factors in the blood-clotting process
This chart is a simplified visualization of Bypassing Agent activity in the blood-clotting process.
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